Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-circulation

This clinical consensus statement from the European Society of Cardiology defines perivascular adipose tissue (PVAT) and highlights the biological mechanisms that underline its utility as both a diagnostic and prognostic biomarker, and therapeutic target, in cardiovascular disease.

In this article, PVAT’s role as a ‘biosensor’ of vascular inflammation is demonstrated with a review of clinical studies revealing its added prognostic value for major cardiac events over other biomarkers, including CRP and high-risk plaque features.

The consensus statement also describes recent imaging technologies that visualise PVAT in clinical practice, including the CaRi-Heart® FAI-Score, allowing non-invasive quantification of coronary inflammation and the related cardiovascular risk, guiding deployment therapeutic interventions. Read the entire publication here.

Charalambos Antoniades, Dimitris Tousoulis, Marija Vavlukis, Ingrid Fleming, Dirk J Duncker, Etto Eringa, Olivia Manfrini, Alexios S Antonopoulos, Evangelos Oikonomou, Teresa Padró, Danijela Trifunovic-Zamaklar, Giuseppe De Luca, Tomasz Guzik, Edina Cenko, Ana Djordjevic-Dikic, Filippo Crea, Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-circulation, European Heart Journal, 2023;, ehad484, https://doi.org/10.1093/eurheartj/ehad484