Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-circulation | Antoniades et al.

Perivascular adipose tissue (PVAT) as a source of imaging biomarkers and a therapeutic target. FAI, fat attenuation index.

This clinical consensus statement from the European Society of Cardiology defines perivascular adipose tissue (PVAT) and highlights the biological mechanisms that underline its utility as both a diagnostic and prognostic biomarker, and therapeutic target, in cardiovascular disease.

In this article, PVAT’s role as a ‘biosensor’ of vascular inflammation is demonstrated with a review of clinical studies revealing its added prognostic value for major cardiac events over other biomarkers, including CRP and high-risk plaque features.

The consensus statement also describes recent imaging technologies that visualise PVAT in clinical practice, including the CaRi-Heart® FAI-Score, allowing non-invasive quantification of coronary inflammation and the related cardiovascular risk, guiding deployment therapeutic interventions. Read the entire publication here.

 

Charalambos Antoniades, Dimitris Tousoulis, Marija Vavlukis, Ingrid Fleming, Dirk J Duncker, Etto Eringa, Olivia Manfrini, Alexios S Antonopoulos, Evangelos Oikonomou, Teresa Padró, Danijela Trifunovic-Zamaklar, Giuseppe De Luca, Tomasz Guzik, Edina Cenko, Ana Djordjevic-Dikic, Filippo Crea, Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-circulation, European Heart Journal, 2023;, ehad484, https://doi.org/10.1093/eurheartj/ehad484