News

European Society of Cardiology: Coronary computed tomography angiography (CTA) is an established and highly sensitive non-invasive technique to detect obstructive and non-obstructive coronary artery disease (CAD). However, it has not been well-studied as a technique to detect inflammatory changes (or its impact on future coronary...

Caristo Diagnostics is proud to have been part of the bid which secured funding for NCIMI in Oxford. University of Oxford: Innovate UK and industry are to invest more than £17.5 million in the University of Oxford to develop artificial intelligence (AI) healthcare applications to benefit...

MedScape: Rupture of unstable nonobstructive plaque is the underlying cause of most acute coronary syndromes.[1,2] However, imaging tests to identify high-risk plaque features such as thin-cap fibroatheroma (TCFA) or spotty calcification are not practical for everyday use and have had mixed success for predicting future events. [...

JAMA: A new protocol to rule out myocardial infarctions (MIs), or heart attacks, in emergency departments using a recently approved high-sensitivity troponin t test was found to be safe and accurate in a study published in Circulation. Most US hospitals use an older troponin assay that’s less sensitive and precise than...

OXFORD UNIVERSITY INNOVATION:  Oxford University spinout Caristo Diagnostics utilises standard CT scans to identify potentially heart-stopping plaques. Caristo Diagnostics, an Oxford University spinout company, has been launched to commercialise a new coronary CT image analysis technology that can flag patients at risk of deadly heart...

REUTERS: A new method of analyzing images from CT scans can predict which patients are at risk of a heart attack years before it occurs, researchers say. The technology, developed by teams at Oxford University and institutions in Germany and the United States, uses algorithms to...

NEJM: This study identified a potential novel measure of inflammation that can be derived from standard CTA imaging and correlated with cardiac-related and overall mortality. However, editorialists note the process currently is time consuming and requires specialized expertise, which limits its application. Moreover, although they note...

TOUCH CARDIO: Professor Charalambos Antoniades (Professor of Cardiovascular Medicine, Radcliffe Department of Medicine, Division of Cardiovascular Medicine, University of Oxford, Oxford, UK) discusses the imaging of perivascular fat and computed tomography (CT) technology, with particular emphasis on the results of the CRISP-CT study, presented at ESC...

THE LANCET: Coronary artery inflammation inhibits adipogenesis in adjacent perivascular fat. A novel imaging biomarker—the perivascular fat attenuation index (FAI)—captures coronary inflammation by mapping spatial changes of perivascular fat attenuation on coronary computed tomography angiography (CTA). However, the ability of the perivascular FAI to predict...

THE GUARDIAN: Researchers says colour of fat surrounding a heart’s arteries can predict risk, meaning expensive drugs can be given to those most likely to benefit. Heart attacks may soon be easier to predict thanks to a method of reading routine heart scans that can pinpoint...

JAMA: A team led by scientists at the University of Oxford has developed the first method to detect inflammation in the heart’s blood vessels using a standard clinical imaging procedure, computed tomographic (CT) angiography. Inflammation contributes to both the formation of arterial plaques and their...

BRITISH HEART FOUNDATION:  Scientists at the University of Oxford have developed a new type of imaging test, based on Computed Tomography (CT) angiography, that could provide an early warning of coronary heart disease. They have now been awarded a grant of £287,000 by the BHF...

NATURE REVIEWS CARDIOLOGY: A novel image-analysis method using standard CT imaging demonstrates that changes in the CT signal of coronary perivascular adipose tissue are associated with the degree of inflammation in adjacent coronary plaques. This exciting development might become a useful adjuvant clinical tool, although...

BBC NEWS: Scientists have developed a new way of scanning the heart that could predict who will have a heart attack. It has the potential to revolutionise treatment for one of the biggest killers in the world, says the team at the University of Oxford....

SCIENCE TRANSLATIONAL MEDICINE: Early detection of vascular inflammation would allow deployment of targeted strategies for the prevention or treatment of multiple disease states. Because vascular inflammation is not detectable with commonly used imaging modalities, we hypothesized that phenotypic changes in perivascular adipose tissue (PVAT) induced by...

NBC NEWS: Researchers say they’ve developed a better way of scanning someone’s heart to predict who is most at risk of a heart attack or stroke — long before conventional imaging methods can do it. By the time someone knows he or she has blocked arteries, it’s too...