Detecting Coronary Inflammation with Perivascular Fat Attenuation Imaging: Making Sense from Perivascular Attenuation Maps
Inflammation has long been implicated in human atherogenesis, which has been confirmed by recent clinical trials. Although simple therapeutic interventions such as statins reduce vascular inflammation, significant residual inflammatory risk remains.
Noninvasive imaging using positron emission tomography (PET) can indirectly detect coronary inflammation, but is expensive and requires high-end equipment. The development of more accessible noninvasive imaging methods to identify coronary inflammation would allow targeted deployment of anti-inflammatory treatments, which would facilitate a more personalized approach to individual care.
Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-circulation
This clinical consensus statement from the European Society of Cardiology defines perivascular adipose tissue (PVAT) and highlights the biological mechanisms…
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
Abstract: Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic cardiovascular complications up to 1 year after infection. Although…