Current Evidence and Recommendations for Coronary CTA First in Evaluation of Stable Coronary Artery Disease
In the United States, functional imaging is the most commonly used method to diagnose potentially obstructive coronary artery disease (CAD) in patients with stable chest pain. However, evidence from several contemporary randomized clinical trials may advocate a new paradigm of imaging for detecting coronary atherosclerosis, not only stenosis, in low- to moderate-risk patients. Evidence from the U.K.SCOT-HEART (Scottish Computed Tomography of the Heart) trial (1) and the U.S. PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) trial (2) suggests that the current aim of diagnosis of stable chest pain in patients with possible obstructive CAD must change from detection of a myocardial perfusion abnormality to detection of coronary atherosclerosis, by using a coronary computed tomography (CT) angiography (CTA)–first strategy. This important scientific advance should become the critical focus of testing.
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Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-circulation
This clinical consensus statement from the European Society of Cardiology defines perivascular adipose tissue (PVAT) and highlights the biological mechanisms…
SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels
Abstract: Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic cardiovascular complications up to 1 year after infection. Although…